What is Semaglutide?

Semaglutide, also known as the brand names Ozempic or Rybelsus, works by reducing your appetite and so helps you lose weight. It mimicks the effects of GLP-1 which is a hormone released by your gut. This hormone binds to the GLP-1 receptor in your brain which reduces hunger pangs, slows down the digestive process and makes you feel fuller for longer. Please note Ozempic and Rybelsus are currently off-licence when used as a treatment for weight loss.

How do I take it?

Rybelsus is the tablet version of Semaglutide which is taken daily at the same time each day.

For Rybelsus:

• The starting dose is 3mg once a day for four weeks.  This gives your body a chance to get used to the medication.
• After four weeks you will increase your dose to 7 mg once a day.
• After a further four weeks you will increase your dose to 14mg per day.

How is the injection given?

Semaglutide can be given as a subcutaneous injection just under the skin.

The best places to give the injection are the front of your thighs, the front of your waist (abdomen), or your upper arm.

Before you use the pen for the first time, please watch the video below for instruction on how to use it.

https://www.ozempic.com/how-to-take/ozempic-pen.html

When should I use Semaglutide?

Your should take the tablet at the same time each day.

You should use the injectable version once a week on the same day each week if possible.

You can give yourself the injection at any time of the day – regardless of meals.

If necessary you can change the day of your weekly injection of this medicine as long as it has been at least 3 days since your last injection of it. After selecting a new dosing day, continue with once a week dosing.

How effective is it?

About 4 times more effective than just making dietary changes with increased exercise! Patients are expected to lose about 10% of their bodyweight after about 6 months after treatment with Semaglutide plus lifestyle interventions compared to around 2.5% with just lifestyle interventions alone.¹ This increases to around 15% after a year of using the medication with appropriate lifestyle changes! 

¹ https://www.nejm.org/doi/full/10.1056/NEJMoa2032183

What are the side effects on Semaglutide?

Like all medications, Semaglutide can give you side effects, although not everyone gets them. The main side effects are feeling sick and diarrhoea, but these go away over time. Other side effects which usually go away over time are abdominal pain and taste changes. An uncommon side effect is bruising or irritation around the injection site. Please see the patient information leaflet in the medication box for further details.

Who is eligible?

Please take our questionnaire to see if you are eligible. Semaglutide should only be used in patients with a BMI >30 or BMI >27 if they have certain medical conditions, such as high blood pressure.